Kulcsár G, Dán P, Horváth J, Nász I
Acta Microbiol Hung. 1984;31(1):49-53.
The course of infection by human adenovirus type 12 has been studied in mice treated with phytohaemagglutinin (PHA) 1 day after infection or those infected with the virus 3 days after PHA treatment. Virus antigens were demonstrated by immunofluorescence in the cells of the thymus, spleen and lymph nodes and in some cases the supernatant of the cell homogenate was found to contain infective viruses. Virus antigens occurred sporadically in cells of the lymphoid organs of control animals infected only with adenovirus. Neither virus antigens nor infective virus could be detected in mice that were not infected by virus and not treated with PHA as controls. The results indicate that PHA treatment increased the sensitivity of mice to human adenovirus infection.
对感染人12型腺病毒的病程进行了研究，实验对象为感染后1天用植物血凝素（PHA）处理的小鼠，或PHA处理3天后感染该病毒的小鼠。通过免疫荧光法在胸腺、脾脏和淋巴结的细胞中检测到病毒抗原，在某些情况下，细胞匀浆的上清液中发现含有感染性病毒。仅感染腺病毒的对照动物的淋巴器官细胞中偶尔出现病毒抗原。未感染病毒且未用PHA处理作为对照的小鼠中，既未检测到病毒抗原也未检测到感染性病毒。结果表明，PHA处理增加了小鼠对人腺病毒感染的敏感性。
