Horváth J, Kulcsár G, Ugryumov J P, Dás P, Nász I, Barinsky I F, Simon G, Ongrádi J
Acta Microbiol Hung. 1983;30(3-4):203-9.
The effect of adenovirus infection on human peripheral lymphocytes has been studied in vitro. Virus antigens were found to multiply in the cell cultures but no infective virus was formed. On infecting the lymphocytes after stimulation with phytohaemagglutinin, infective virus was formed though in low titre. Adenovirus infection decreased the E-rosette forming activity and the response to phytohaemagglutinin of the lymphocytes. The immunomodulating drug levamisole failed to influence significantly the effect of the virus. Adenovirus thus causes several changes in the characteristics of peripheral lymphocytes which may lead to a disturbance of the immune function.
已在体外研究了腺病毒感染对人外周淋巴细胞的影响。发现病毒抗原在细胞培养物中增殖，但未形成感染性病毒。在用植物血凝素刺激后感染淋巴细胞时，虽形成了感染性病毒，但滴度较低。腺病毒感染降低了淋巴细胞的E-玫瑰花结形成活性以及对植物血凝素的反应。免疫调节药物左旋咪唑未能显著影响病毒的作用。因此，腺病毒会导致外周淋巴细胞特性发生多种变化，这可能会导致免疫功能紊乱。
