Markman M, Braine H G, Abeloff M D
Cancer. 1984 Dec 15;54(12):2943-5. doi: 10.1002/1097-0142(19841215)54:12<2943::aid-cncr2820541221>3.0.co;2-#.
Fifty white patients with small cell carcinoma of the lung (SCCL) were typed for histocompatibility antigens (HLA) to assist in providing platelet support for intensive induction therapy. An analysis of the HLA types in this population was undertaken to determine if there was an influence of HLA type on this disease. Patients with the HLA-Bw44 (HLA-B12) allele were found to be significantly over-represented in our patient population compared to a control population (52% versus 26%, P less than 0.001). In addition, patients possessing the HLA-A1 phenotype were found to have a significantly poorer 1-year survival rate (15%) than individuals who did not possess this allele (60% 1-year survival rate) (P less than 0.025). These findings will need to be confirmed by other groups working with large numbers of patients with SCCL.
五十名患有肺小细胞癌（SCCL）的白人患者进行了组织相容性抗原（HLA）分型，以协助为强化诱导治疗提供血小板支持。对该人群的HLA类型进行了分析，以确定HLA类型是否对这种疾病有影响。与对照人群相比，发现携带HLA - Bw44（HLA - B12）等位基因的患者在我们的患者群体中显著过多（52%对26%，P小于0.001）。此外，发现具有HLA - A1表型的患者1年生存率（15%）明显低于不携带该等位基因的个体（1年生存率60%）（P小于0.025）。这些发现需要其他研究大量肺小细胞癌患者的团队加以证实。
