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用周期基因座DNA进行P因子转化可使突变的、无节律的黑腹果蝇恢复节律性。

P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster.

作者信息

Zehring W A, Wheeler D A, Reddy P, Konopka R J, Kyriacou C P, Rosbash M, Hall J C

出版信息

Cell. 1984 Dec;39(2 Pt 1):369-76. doi: 10.1016/0092-8674(84)90015-1.

DOI:10.1016/0092-8674(84)90015-1
PMID:6094014
Abstract

Mutations at the period (per) locus of Drosophila melanogaster disrupt several biological rhythms. Molecular cloning of DNA sequences encompassing the per+ locus has allowed germ-line transformation experiments to be carried out. Certain subsegments of the per region, transduced into the genome of arrhythmic pero flies, restore rhythmicity in circadian locomotor behavior and the male's courtship song.

摘要

黑腹果蝇周期（per）基因座的突变会扰乱多种生物节律。对包含per +基因座的DNA序列进行分子克隆，使得生殖系转化实验得以开展。将per区域的某些亚片段导入无节律的pero果蝇基因组后，可恢复其昼夜运动行为和雄性求偶歌声的节律性。

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P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster.用周期基因座DNA进行P因子转化可使突变的、无节律的黑腹果蝇恢复节律性。
Cell. 1984 Dec;39(2 Pt 1):369-76. doi: 10.1016/0092-8674(84)90015-1.
2
Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song.黑腹果蝇的昼夜节律突变会影响雄性求偶歌声的短期波动。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6729-33. doi: 10.1073/pnas.77.11.6729.
3
Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants.
J Neurogenet. 1986 Sep;3(5):249-91. doi: 10.3109/01677068609106855.
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Restoration of circadian behavioural rhythms by gene transfer in Drosophila.通过基因转移恢复果蝇的昼夜行为节律。
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Product of per locus of Drosophila shares homology with proteoglycans.果蝇每个基因座的产物与蛋白聚糖具有同源性。
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Courtship bout duration in per circadian period mutants in Drosophila melanogaster.黑腹果蝇昼夜节律周期突变体的求偶回合持续时间。
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Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila.通过对果蝇周期基因内可变区进行体外诱变来改变行为。
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Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster.果蝇周期基因中导致生物钟停止或加速的点突变的分子图谱。
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The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs.黑腹果蝇无瞬态A位点的失调突变：具有假定RNA结合基序的蛋白质对求偶歌声和视觉行为的遗传控制
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J Neurogenet. 1996 Dec;11(1-2):117-39. doi: 10.3109/01677069609107066.

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