Isaacs D, Clarke J R, Tyrrell D A, Valman H B
Br Med J (Clin Res Ed). 1982 Jun 12;284(6331):1746-8. doi: 10.1136/bmj.284.6331.1746.
Thirty preschool children presenting with recurrent respiratory infections and their unaffected siblings were observed prospectively for a year. The index children experienced more episodes of acute respiratory infection than their siblings. Respiratory viruses were the major cause of respiratory infections. The index children had lower respiratory tract disease, predominantly wheeze, during 34% of proved respiratory virus infections compared with 11% of such infections experienced by the control children (p less than 0.02). Atopic children had an increased tendency to wheeze that did not reach significance, but atopy was not associated with increased susceptibility to respiratory infections.
对30名患有反复呼吸道感染的学龄前儿童及其未受感染的兄弟姐妹进行了为期一年的前瞻性观察。与他们的兄弟姐妹相比，这些受试儿童经历了更多的急性呼吸道感染发作。呼吸道病毒是呼吸道感染的主要原因。在经证实的呼吸道病毒感染中，受试儿童有34%发生了下呼吸道疾病，主要是喘息，而对照儿童在这类感染中的发生率为11%（P<0.02）。特应性儿童喘息的倾向增加，但未达到显著水平，而且特应性与呼吸道感染易感性增加无关。
