Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis.
作者信息
Peretti P, Sueri L, Tosi M, Ciammarughi R, Cadeo G P, Milanesi B
出版信息
J Antimicrob Chemother. 1984 Sep;14 Suppl B:117-23. doi: 10.1093/jac/14.suppl_b.117.
PMID:6094430
Abstract
Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum.
摘要
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