亚洲猴类登革病毒和日本脑炎病毒感染的血清流行病学调查。

Seroepidemiological survey on dengue and Japanese encephalitis virus infections in Asian monkeys.

作者信息

Yuwono J, Suharyono W, Koiman I, Tsuchiya Y, Tagaya I

出版信息

Southeast Asian J Trop Med Public Health. 1984 Jun;15(2):194-200.

Abstract

To investigate the ecology of dengue and Japanese encephalitis (JE) viruses in the forest in Asia, a seroepidemiological survey was carried out on 358 Southeast Asian cynomolgus (Macaca iris), 33 Indian bonnet (Macaca radiata) and 37 Japanese (Macaca fuscata) monkey sera by a plaque reduction neutralization test. The results indicated that Southeast Asian monkeys were naturally infected with these viruses but the frequency of antibody to them varied considerably according to the geographical origin of the monkeys. The frequency of antibody to one or more types of dengue virus were 87.2, 49.5, 34.3, 34.2 and 14.9% in Malaysian, Vietnamese, Cambodian, Indonesian and Filipino cynomolgus monkey sera, respectively. None of the Indian bonnet monkey sera neutralized type 1 dengue virus which was the only virus type examined with this monkey species. Monkey sera collected in Japan where dengue virus infection had not been known since 1944 did not significantly neutralize dengue viruses. JE virus antibody was detected at 29.7, 9.0, 8.6, 2.7, 1.4 and 0% in Japanese, Cambodian, Vietnamese, Indonesian, Filipino and Malaysian monkey sera respectively.

摘要

为了调查亚洲森林中登革热病毒和日本脑炎（JE）病毒的生态学，通过蚀斑减少中和试验对358份东南亚食蟹猴（食蟹猕猴）、33份印度冠猴和37份日本猕猴的血清进行了血清流行病学调查。结果表明，东南亚猴子自然感染了这些病毒，但针对它们的抗体频率根据猴子的地理来源有很大差异。马来西亚、越南、柬埔寨、印度尼西亚和菲律宾食蟹猴血清中针对一种或多种登革热病毒的抗体频率分别为87.2%、49.5%、34.3%、34.2%和14.9%。印度冠猴血清中没有一种能中和1型登革热病毒，这是该猴种唯一检测的病毒类型。1944年以来日本未曾有登革热病毒感染的报道，采集的日本猕猴血清对登革热病毒无明显中和作用。日本、柬埔寨、越南、印度尼西亚、菲律宾和马来西亚猴子血清中日本脑炎病毒抗体的检测率分别为29.7%、9.0%、8.6%、2.7%、1.4%和0%。