在脱氧助间型霉素存在的情况下对阿糖腺苷耐药的单纯疱疹病毒突变体
Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.
作者信息
Fleming H E, Coen D M
出版信息
Antimicrob Agents Chemother. 1984 Sep;26(3):382-7. doi: 10.1128/AAC.26.3.382.
Abstract
Herpes simplex virus mutants PAAr5, AraAr6, AraAr7, AraAr9, and AraAr13, which previously had been shown to be resistant to arabinosyladenine (araA) alone, were found to be resistant to araA in the presence of high concentrations of the adenosine deaminase inhibitor, deoxycoformycin. The marker conferring resistance to araA and deoxycoformycin in mutant PAAr5 was mapped finely to an 0.8-kilobase-pair region in the herpes simplex virus DNA polymerase locus. These results indicate that the mutants are resistant to araA itself rather than to its deamination product and confirm the importance of the viral polymerase in the antiviral action of araA.
摘要
单纯疱疹病毒突变体PAAr5、AraAr6、AraAr7、AraAr9和AraAr13，此前已被证明单独对阿糖腺苷（araA）具有抗性，结果发现它们在高浓度腺苷脱氨酶抑制剂脱氧助间型霉素存在的情况下对araA也具有抗性。赋予突变体PAAr5对araA和脱氧助间型霉素抗性的标记被精细定位到单纯疱疹病毒DNA聚合酶基因座中的一个0.8千碱基对区域。这些结果表明，这些突变体对araA本身具有抗性，而不是对其脱氨产物具有抗性，并证实了病毒聚合酶在araA抗病毒作用中的重要性。
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