1型单纯疱疹病毒阿昔洛韦耐药突变体的生化与遗传学分析 - Suppr

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Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1.

作者信息

Coen D M, Schaffer P A, Furman P A, Keller P M, St Clair M H

出版信息

Am J Med. 1982 Jul 20;73(1A):351-60. doi: 10.1016/0002-9343(82)90122-x.

DOI:10.1016/0002-9343(82)90122-x

PMID:6285722

Abstract

摘要

相似文献

Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1.1型单纯疱疹病毒阿昔洛韦耐药突变体的生化与遗传学分析

Am J Med. 1982 Jul 20;73(1A):351-60. doi: 10.1016/0002-9343(82)90122-x.

Genetic mechanisms of resistance to acyclovir in herpes simplex virus.单纯疱疹病毒对阿昔洛韦耐药的遗传机制。

Am J Med. 1982 Jul 20;73(1A):361-8. doi: 10.1016/0002-9343(82)90123-1.

Resistance of herpes simplex virus to acycloguanosine--genetic and physical analysis.

Virology. 1980 Aug;105(1):171-84. doi: 10.1016/0042-6822(80)90165-8.

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.1型单纯疱疹病毒的阿昔洛韦耐药突变体表现出DNA聚合酶改变或阿昔洛韦磷酸化活性降低。

J Virol. 1981 Dec;40(3):936-41. doi: 10.1128/JVI.40.3.936-941.1981.

Isolation and characterization of acyclovir-resistant strains of herpes simplex virus.单纯疱疹病毒阿昔洛韦耐药株的分离与鉴定

Am J Med. 1982 Jul 20;73(1A):369-71. doi: 10.1016/0002-9343(82)90124-3.

Drug-resistant herpes simplex virus in vitro and after acyclovir treatment in an immunocompromised patient.免疫功能低下患者体内耐阿昔洛韦的单纯疱疹病毒及其体外研究

Am J Med. 1982 Jul 20;73(1A):387-92. doi: 10.1016/0002-9343(82)90129-2.

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.两个不同的基因座赋予单纯疱疹病毒1型对阿昔洛韦的抗性。

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2265-9. doi: 10.1073/pnas.77.4.2265.

The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.单纯疱疹病毒的阿昔洛韦耐药突变体对其他抗病毒药物的敏感性。

J Infect Dis. 1981 Feb;143(2):281-5. doi: 10.1093/infdis/143.2.281.

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.单纯疱疹病毒阿拉伯糖腺嘌呤抗性突变体对其他抗病毒药物的敏感性以及药物超敏突变在DNA聚合酶基因座上的定位。

J Virol. 1985 Feb;53(2):477-88. doi: 10.1128/JVI.53.2.477-488.1985.

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.单纯疱疹病毒对阿昔洛韦的耐药性：病毒胸苷激酶和DNA聚合酶基因座的作用。

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2270-3. doi: 10.1073/pnas.77.4.2270.

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A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs' Susceptibility.单纯疱疹病毒1型（HSV-1）UL29基因的突变与抗疱疹病毒药物敏感性相关。

Viruses. 2024 Nov 21;16(12):1813. doi: 10.3390/v16121813.

Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.阿昔洛韦、膦甲酸钠和核糖核苷酸对单纯疱疹病毒1型DNA聚合酶的影响：作用机制解析及防止核糖核苷酸稳定掺入DNA的新机制

Biochemistry. 2016 Feb 23;55(7):1168-77. doi: 10.1021/acs.biochem.6b00065. Epub 2016 Feb 11.

Development and evaluation of SYBR Green-I based quantitative PCR assays for herpes simplex virus type 1 whole transcriptome analysis.SYBR Green-I 定量 PCR 法检测单纯疱疹病毒 1 型全转录组分析的建立与评价。

J Virol Methods. 2014 Jun;201:101-11. doi: 10.1016/j.jviromet.2014.02.010. Epub 2014 Mar 4.

Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.在一轮高剂量溴夫定作用下筛选出的单纯疱疹病毒1型胸苷激酶突变体的特性分析

J Virol. 2005 May;79(9):5863-9. doi: 10.1128/JVI.79.9.5863-5869.2005.

Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.在阿昔洛韦或喷昔洛韦存在的情况下传代的1型单纯疱疹病毒克隆的胸苷激酶和DNA聚合酶基因中的差异突变模式。

Antimicrob Agents Chemother. 2003 May;47(5):1707-13. doi: 10.1128/AAC.47.5.1707-1713.2003.

Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses.骆驼痘病毒、牛痘病毒、猴痘病毒和痘苗病毒野生型及西多福韦耐药株的特性分析

Antimicrob Agents Chemother. 2002 May;46(5):1329-35. doi: 10.1128/AAC.46.5.1329-1335.2002.

Frequency of acyclovir-resistant herpes simplex virus in clinical specimens and laboratory isolates.临床标本和实验室分离株中阿昔洛韦耐药单纯疱疹病毒的频率

J Clin Microbiol. 2001 Mar;39(3):913-7. doi: 10.1128/JCM.39.3.913-917.2001.

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.单纯疱疹病毒DNA聚合酶基因座突变的精细定位与分子克隆

J Virol. 1984 Jan;49(1):236-47. doi: 10.1128/JVI.49.1.236-247.1984.

Sequence analyses of herpesviral enzymes suggest an ancient origin for human sexual behavior.疱疹病毒酶的序列分析表明人类性行为起源古老。

Proc Natl Acad Sci U S A. 1988 Apr;85(8):2658-61. doi: 10.1073/pnas.85.8.2658.

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.在病毒DNA聚合酶基因中含有耐药性突变的单纯疱疹病毒突变体的致病性。

J Virol. 1986 Oct;60(1):286-9. doi: 10.1128/JVI.60.1.286-289.1986.

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