在病毒DNA聚合酶基因中含有耐药性突变的单纯疱疹病毒突变体的致病性。
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
作者信息
Field H J, Coen D M
出版信息
J Virol. 1986 Oct;60(1):286-9. doi: 10.1128/JVI.60.1.286-289.1986.
Abstract
Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.
摘要
三个在DNA聚合酶基因中含有耐药性突变的单纯疱疹病毒突变体，在耳部接种后与野生型相比，在小鼠耳部的复制没有显著减少，但在脑内接种后致病性减弱。白内障是存活于突变体感染后的小鼠常见的后遗症。
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