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本文引用的文献

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The development of retinitis in mice with nonfatal herpes simplex encephalitis.
Neuropathol Appl Neurobiol. 1982 Jul-Aug;8(4):277-87. doi: 10.1111/j.1365-2990.1982.tb00297.x.
2
Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy.接受口服治疗的单纯疱疹病毒感染小鼠对阿昔洛韦产生临床耐药性的研究。
Antimicrob Agents Chemother. 1982 May;21(5):744-52. doi: 10.1128/AAC.21.5.744.
3
Characterization of latent infections in mice inoculated with herpes simplex virus which is clinically resistant to acyclovir.对接种对阿昔洛韦临床耐药的单纯疱疹病毒的小鼠潜伏感染的特征分析。
Antiviral Res. 1984 Apr;4(1-2):43-52. doi: 10.1016/0166-3542(84)90024-x.
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Virus drug-resistance: mechanisms and consequences.病毒耐药性：机制与后果
Antiviral Res. 1984 Apr;4(1-2):1-42. doi: 10.1016/0166-3542(84)90023-8.
5
Cooperative effects between two acyclovir resistance loci in herpes simplex virus.单纯疱疹病毒中两个阿昔洛韦抗性位点之间的协同效应。
J Virol. 1984 Jun;50(3):838-46. doi: 10.1128/JVI.50.3.838-846.1984.
6
Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.BW759U的三磷酸盐对细胞α-DNA聚合酶和单纯疱疹病毒诱导的DNA聚合酶的抑制作用。
Antimicrob Agents Chemother. 1984 Feb;25(2):191-4. doi: 10.1128/AAC.25.2.191.
7
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.单纯疱疹病毒遗传多样性的产生：一种抗突变表型定位于DNA聚合酶基因座。
Virology. 1984 Jan 15;132(1):26-37. doi: 10.1016/0042-6822(84)90088-6.
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Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.单纯疱疹病毒DNA聚合酶基因座突变的精细定位与分子克隆
J Virol. 1984 Jan;49(1):236-47. doi: 10.1128/JVI.49.1.236-247.1984.
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Drug therapy. Treatment of herpesvirus infections.药物治疗。疱疹病毒感染的治疗。
N Engl J Med. 1983 Oct 27;309(17):1034-9. doi: 10.1056/NEJM198310273091706.
10
The distribution of herpes simplex type 1 antigen in mouse central nervous system after different routes of inoculation.接种不同途径后单纯疱疹病毒1型抗原在小鼠中枢神经系统中的分布
J Neurol Sci. 1983 Aug;60(2):181-95. doi: 10.1016/0022-510x(83)90061-8.

在病毒DNA聚合酶基因中含有耐药性突变的单纯疱疹病毒突变体的致病性。

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.

作者信息

Field H J, Coen D M

出版信息

J Virol. 1986 Oct;60(1):286-9. doi: 10.1128/JVI.60.1.286-289.1986.

DOI:10.1128/JVI.60.1.286-289.1986
PMID:3018291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253927/
Abstract

Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.

摘要

三个在DNA聚合酶基因中含有耐药性突变的单纯疱疹病毒突变体，在耳部接种后与野生型相比，在小鼠耳部的复制没有显著减少，但在脑内接种后致病性减弱。白内障是存活于突变体感染后的小鼠常见的后遗症。