单纯疱疹病毒DNA聚合酶基因内赋予对（R）-9-（3,4-二羟基丁基）鸟嘌呤抗性的突变。
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.
作者信息
Chiou H C, Kerns K M, Coen D M
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):502-4. doi: 10.1128/AAC.30.3.502.
Abstract
Five herpes simplex virus mutants known or presumed to contain mutations in their DNA polymerase genes conferring resistance to acyclovir and arabinosyladenine also proved to exhibit some degree of resistance to (R)-9-(3,4-dihydroxybutyl)guanine (buciclovir). For one mutant, a buciclovir resistance mutation was mapped to a region of the viral DNA polymerase gene proposed to encode the deoxynucleoside 5'-triphosphate binding domain. These data implicate the viral polymerase as a target of buciclovir action that contributes to its antiviral selectivity.
摘要
已知或推测其DNA聚合酶基因发生突变而对阿昔洛韦和阿糖腺苷产生耐药性的五种单纯疱疹病毒突变体，也被证明对（R）-9-（3,4-二羟基丁基）鸟嘌呤（布昔洛韦）表现出一定程度的耐药性。对于其中一个突变体，布昔洛韦耐药性突变被定位到病毒DNA聚合酶基因的一个区域，该区域被认为编码脱氧核苷5'-三磷酸结合结构域。这些数据表明病毒聚合酶是布昔洛韦作用的靶点，这有助于其抗病毒选择性。
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