Booss J, Kim J H
Yale J Biol Med. 1984 Sep-Oct;57(5):751-5.
The histopathology of herpes simplex encephalitis (HSE) has been described principally from postmortem studies which reveal end-stage disease. Biopsy material, which selects an earlier stage in disease development, has been used principally to isolate virus, identify viral particles, and locate viral antigens. Further, little attention has been paid to the histopathology of biopsies of encephalitis of undefined etiology. In the present study, sections from biopsies which yielded virus and those which were negative for virus were evaluated in a systematic and controlled manner. Biopsies yielding virus were characterized by meningeal inflammation, perivascular infiltrates, and glial nodules. Biopsies which did not yield virus and which failed to reveal another diagnosis were characterized by nonspecific gliosis. Thus the early histiopathology of HSE is characterized by early signs of inflammation in the absence of necrosis and generally differs from biopsies in which virus is not isolated.
单纯疱疹性脑炎（HSE）的组织病理学主要是根据尸检研究描述的，这些研究揭示的是疾病的终末期情况。活检材料选取的是疾病发展的早期阶段，主要用于分离病毒、识别病毒颗粒以及定位病毒抗原。此外，对于病因不明的脑炎活检组织病理学关注甚少。在本研究中，对病毒检测呈阳性和阴性的活检切片进行了系统且可控的评估。病毒检测呈阳性的活检组织表现为脑膜炎症、血管周围浸润和胶质结节。未检测出病毒且未发现其他诊断结果的活检组织表现为非特异性胶质增生。因此，HSE的早期组织病理学特征是在无坏死情况下出现早期炎症迹象，通常与未分离出病毒的活检组织不同。
