黄曲霉毒素中毒对雄性大鼠大脑和腺垂体乙酰胆碱酯酶活性的影响。

Effect of aflatoxicosis on acetylcholinesterase activity in the brain and adenohypophysis of the male rat.

作者信息

Egbunike G N, Ikegwuonu F I

出版信息

Neurosci Lett. 1984 Nov 23;52(1-2):171-4. doi: 10.1016/0304-3940(84)90369-0.

Abstract

The effects of 7 or 42 48-hourly i.p. injections of 20 micrograms aflatoxin B1 (AFB) on the acetylcholinesterase activity (AChE) in 8 brain areas and the adenohypophysis of the adult male rat were studied. Aflatoxicosis increased adenohypophysial AChE in direct proportion to the duration of intoxication, which also altered the distribution of AChE in the rat brain. With acute treatment, AChE was depressed in the cerebellum and hippocampus while in the chronically dosed rats AChE was drastically elevated in the mesencephalon and amygdala. Results suggest that AFB changes the ACh turnover and hence the cholinergic transmission in the brain and adenohypophysis. This may result in behavioural deficits and/or performance decrements via a disturbance of the hypothalamo-hypophysial axis.

摘要

研究了成年雄性大鼠经腹腔注射每48小时一次、每次20微克黄曲霉毒素B1（AFB），连续注射7次或42次后，对其8个脑区及腺垂体乙酰胆碱酯酶活性（AChE）的影响。黄曲霉毒素中毒使腺垂体AChE活性与中毒持续时间成正比增加，同时也改变了大鼠脑中AChE的分布。急性处理时，小脑和海马中的AChE活性降低，而长期给药的大鼠中脑和杏仁核中的AChE活性急剧升高。结果表明，AFB改变了大脑和腺垂体中的乙酰胆碱周转，从而改变了胆碱能传递。这可能通过干扰下丘脑 - 垂体轴导致行为缺陷和/或性能下降。