新型半合成头孢菌素E-0702的体外抗菌活性
In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin.
作者信息
Katsu K, Kitoh K, Inoue M, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1982 Aug;22(2):181-5. doi: 10.1128/AAC.22.2.181.
Abstract
E-0702 is an antipseudomonal cephalosporin derivative which has a broad spectrum of antibacterial activity against clinical isolates of gram-positive and gram-negative bacteria. Its in vitro antibacterial activities were less than those of cefoperazone and cefotaxime against Staphylococcus aureus and Staphylococcus epidermidis, but were significantly high against gram-negative bacteria including the Pseudomonas group. It was most characteristic that E-0702 showed high antibacterial activity against Pseudomonas aeruginosa. E-0702 was relatively stable to inactivation by plasmid-mediated penicillinases and cephalosporinases produced by gram-negative bacteria.
摘要
E-0702是一种抗假单胞菌头孢菌素衍生物，对革兰氏阳性菌和革兰氏阴性菌的临床分离株具有广谱抗菌活性。其对金黄色葡萄球菌和表皮葡萄球菌的体外抗菌活性低于头孢哌酮和头孢噻肟，但对包括假单胞菌属在内的革兰氏阴性菌具有显著高的活性。E-0702对铜绿假单胞菌显示出高抗菌活性是其最显著的特点。E-0702对革兰氏阴性菌产生的质粒介导的青霉素酶和头孢菌素酶的失活相对稳定。
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