Blejer J L, Galassi N V, Nejamkis M R
Cátedra de Microbiología, Parasitología e Inmunología, Facultad de Medicina, UBA, Argentina.
Rev Argent Microbiol. 1983;15(4):223-5.
The susceptibility of the rat, infected at various ages by intraperitoneal route with the XJ prototype strain of Junin virus was studied two day-old animals showed maximum mortality, being the most suitable dose 10(3) LD50. Antiviral humoral response at 35 days pi was tested in survivors of all ages. Highest neutralizing antibody titers were found in those infected up to 4 days of age. This host behaves quite differently when infected by intracerebral route with the same XJ strain.
研究了不同年龄的大鼠经腹腔途径感染胡宁病毒XJ原型株后的易感性。两日龄动物死亡率最高，最适宜剂量为10(3)LD50。对各年龄组存活动物在感染后35天检测了抗病毒体液反应。在4日龄前感染的动物中发现了最高的中和抗体滴度。当用同一XJ株经脑内途径感染时，这种宿主的表现则大不相同。
