Wetterlin S
Acta Chir Scand. 1977;143(7-8):401-6.
Cardiac output distribution, blood pressure and flow in a carotid artery catheter during the first five days after a standardized 15% third degree burn were studied in groups of mice treated with triglycylvasopressin, and in groups used as controls. All animals received isotonic saline solution amounting to 20% of the body weight twice daily, and the treated groups received in addition triglycylvasopressin (TGLVP), a vasopressin analogue with prolonged effect, 100 microgram/kg body weight twice daily. Cardiac output distribution was determined by the 86Rubidium-technique, and showed in burned animals a decreasing fraction to kidneys and small bowel as well as an increased share to the carcass during the experimental period. These changes were partly counteracted by TGLVP-treatment. Flow in the carotid artery catheter in the treated group far exceeded that in the controls, which might be explained by a lower viscosity of the blood in the treated group.
在标准化的15%三度烧伤后的头五天，对用三甘氨酰加压素治疗的小鼠组和作为对照的小鼠组进行了研究，观察心输出量分布、血压以及颈动脉导管中的血流情况。所有动物每天两次接受相当于体重20%的等渗盐溶液，治疗组另外每天两次接受100微克/千克体重的三甘氨酰加压素（TGLVP），一种作用持久的加压素类似物。心输出量分布通过铷-86技术测定，结果显示在实验期间，烧伤动物流向肾脏和小肠的部分减少，而流向躯体的部分增加。这些变化部分被TGLVP治疗所抵消。治疗组颈动脉导管中的血流远远超过对照组，这可能是由于治疗组血液粘度较低所致。
