Vernersson E, Ahlgren I, Aronsen K F, Koopmann H
Acta Chir Scand. 1982;148(6):491-7.
In order to investigate the central and peripheral circulatory effects of a vasoactive drug, lysin vasopressin (LVP), in the early postburn period, 18 piglets were submitted to an experimental study. Anaesthesia was performed by thiopentone sodium as i.v. infusion and mechanically controlled ventilation via endotracheal intubation. Burn injury was brought about by heated metal stamps applied to the back and sides of the animals causing a full thickness skin burn corresponding to 32-35% of the total body surface area. Cardiac output decreased significantly after burn and so did organ blood flow, measured with radioactively labelled microspheres, especially after 4 hours. LVP-infusion did not further decrease cardiac output after burn but decreased the blood flow to the skin, carcass and proximal gastrointestinal tract. The liver perfusion was increased, while the flow in the other organs was not different from that in burned pigs not given LVP. The therapeutical implications are discussed.
为了研究血管活性药物赖氨酸加压素（LVP）在烧伤后早期对中枢和外周循环的影响，对18只仔猪进行了一项实验研究。采用硫喷妥钠静脉输注进行麻醉，并通过气管插管进行机械控制通气。通过将加热的金属印章施加于动物的背部和侧面造成烧伤，导致全层皮肤烧伤，面积相当于体表面积的32% - 35%。烧伤后心输出量显著下降，用放射性标记微球测量的器官血流也显著下降，尤其是在4小时后。输注LVP并没有使烧伤后的心输出量进一步下降，但减少了皮肤、躯体和近端胃肠道的血流。肝脏灌注增加，而其他器官的血流与未给予LVP的烧伤仔猪无差异。文中讨论了其治疗意义。
