Wetterlin S, Aronsen K F, Ahlgren I
Eur Surg Res. 1978;10(2):134-41. doi: 10.1159/000128001.
Earlier published results have shown an increased 5-day survival in burned mice treated with Triglycylvasopressin. In order to analyze the cause of the increased survival, the distribution of cardiac output was studied in 51 mice divided into three groups. The investigation was performed on the 5th day after burn using a soluble indicator technique (86Rb). The first group consisted of unburned animals. In the second and third groups, a standardized burn of 15% of the body surface was undertaken. The animals in the second group were used as controls and received isotonic saline solution for 5 days. The third group were used as controls and received isotonic saline solution and in addition Triglycylvasopressin, a vasopressin with prolonged effect, 100 microgram/kg body weight subcutaneously twice a day in such a way that the total volume of fluid was identical in the different groups. Cardiac output distribution showed an increased fraction to kidney, liver and small bowel and a decreased fraction to carcass in the Triglycylvasopressin-treated animals compared to burned controls.
先前发表的结果显示，用三甘氨酰加压素治疗的烧伤小鼠5天存活率有所提高。为了分析存活率提高的原因，对51只分为三组的小鼠的心输出量分布进行了研究。在烧伤后第5天，采用可溶性指示剂技术（86Rb）进行调查。第一组由未烧伤的动物组成。在第二组和第三组中，进行了15%体表面积的标准化烧伤。第二组动物用作对照，接受等渗盐溶液5天。第三组用作对照，接受等渗盐溶液，此外还皮下注射长效加压素三甘氨酰加压素，剂量为100微克/千克体重，每天两次，以使不同组的液体总量相同。与烧伤对照组相比，三甘氨酰加压素治疗的动物的心输出量分布显示，肾脏、肝脏和小肠的比例增加，而躯体的比例减少。
