肝硬化患者的诱变尿液。

Mutagenic urine in cirrhosis.

作者信息

Gelbart S M, Sontag S J

出版信息

Lancet. 1980 Apr 26;1(8174):894-6. doi: 10.1016/s0140-6736(80)90835-1.

Abstract

Multiple samples of daytime urine from 5 non-smoking patients with cirrhosis, 12 healthy smokers, and 15 healthy non-smokers were collected and analysed for mutagens by the Ames salmonella microsome assay. All 12 samples collected from the 5 cirrhotic patients were mutagenic. 16 of the 17 samples collected from the smokers were mutagenic, while only 2 of the 24 samples from the non-smokers were mutagenic. The discovery of mutagens in the urine of non-smoking patients with cirrhosis is new.

摘要

收集了5名非吸烟肝硬化患者、12名健康吸烟者和15名健康非吸烟者的多份日间尿液样本，并通过埃姆斯沙门氏菌微粒体试验分析其中的诱变剂。从5名肝硬化患者收集的所有12份样本均具有诱变作用。从吸烟者收集的17份样本中有16份具有诱变作用，而从非吸烟者收集的24份样本中只有2份具有诱变作用。在非吸烟肝硬化患者尿液中发现诱变剂这一情况尚属首次。