Hardy J G, Kellaway I W, Rogers J, Wilson C G
J Pharm Pharmacol. 1980 May;32(5):309-13. doi: 10.1111/j.2042-7158.1980.tb12926.x.
The distribution of 131I-labelled liposomes with sodium iodide entrapped in the aqueous core has been compared with that of a preparation containing iodinated phospholipid, following i.v. administration to rabbits. Liver uptake was observed initially with both liposomes, but the distribution of the former preparation soon became indistinguishable from that of [131I] sodium iodide. Iodine-131 was still detectable in the liver 150 h after administration of the phospholipid labelled material. Scintigrams showing the distributions of the radionuclides following administration of 131I-labelled liposomes and 99mTc-DTPA liposomes indicate that there may be some biliary clearance.
将包封有碘化钠的131I标记脂质体的分布情况，与含碘化磷脂制剂在静脉注射给兔后的分布情况进行了比较。两种脂质体最初均观察到肝脏摄取，但前一种制剂的分布很快变得与[131I]碘化钠的分布难以区分。在给予磷脂标记物质150小时后，肝脏中仍可检测到碘-131。显示131I标记脂质体和99mTc-DTPA脂质体给药后放射性核素分布的闪烁图表明可能存在一些胆汁清除。
