Kett K, Aadland E, Berstad A
Scand J Gastroenterol. 1980;15(2):249-51. doi: 10.3109/00365528009181464.
Inhibition of pentagastrin-evoked gastric secretion of acid and pepsin by cimetidine and a new H2-receptor antagonist, ranitidine, was compared in nine healthy young subjects. On separate days cimetidine or ranitidine was administered by continuous intravenous infusions in graded doses. The results demonstrated that the inhibitory effect of ranitidine was 6 and 7.3 times as potent as cimetidine on a weight and a molar basis, respectively.
在9名健康年轻受试者中，比较了西咪替丁和一种新型H2受体拮抗剂雷尼替丁对五肽胃泌素诱发的胃酸和胃蛋白酶分泌的抑制作用。在不同日期，以分级剂量通过持续静脉输注给予西咪替丁或雷尼替丁。结果表明，雷尼替丁的抑制作用在重量基础上是西咪替丁的6倍，在摩尔基础上是西咪替丁的7.3倍。
