Morrison W I, Murray M, Sayer P D, Preston J M
Am J Pathol. 1981 Feb;102(2):168-81.
Inoculation of dogs with Trypanosoma brucei produced an acute fetal disease similar to that seen following natural infection. The disease was characterised by high levels of parasitaemia, moderately severe anemia, and marked changes in the lymphoid system. Extravascular invasion by large numbers of trypanosomes was widespread throughout the body and was accompanied by severe tissue damage. Tissue invasion by trypanosomes was associated with marked cellular infiltration involving lymphoid cells and plasma cells followed by macrophages and polymorphonuclear leukocytes. Associated with these reactions, severe cellular degeneration and focal necrosis occurred. While these changes were widespread and were found in the majority of tissues examined, consistently severe lesions were found in the heart, eyes and central nervous system. In many organs, lymphatic vessels were distended with fluid, trypanosomes, and a cell population similar to that in the surrounding tissue; fibrin deposition and thrombus formation was sometimes observed within the lymphatic lumens. Thrombosis was also found in the blood vessels of the pampiniform plexus, the venous plexus of the ovary, and branches of the renal vein. A severe necrotizing vasculitis affecting only the coronary vessels was a prominent feature in some animals.
用布氏锥虫接种犬可引发一种急性胎儿疾病，类似于自然感染后所见的疾病。该疾病的特征为高寄生虫血症水平、中度严重贫血以及淋巴系统的显著变化。大量锥虫的血管外侵袭遍布全身，并伴有严重的组织损伤。锥虫的组织侵袭与包括淋巴细胞和浆细胞、随后是巨噬细胞和多形核白细胞的显著细胞浸润相关。与这些反应相关的是，出现了严重的细胞变性和局灶性坏死。虽然这些变化广泛存在且在大多数检查的组织中都能发现，但在心脏、眼睛和中枢神经系统中始终发现有严重病变。在许多器官中，淋巴管充满液体、锥虫以及与周围组织相似的细胞群体；有时在淋巴管腔内观察到纤维蛋白沉积和血栓形成。在蔓状静脉丛、卵巢静脉丛和肾静脉分支的血管中也发现了血栓形成。仅影响冠状血管的严重坏死性血管炎是一些动物的突出特征。
