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乳腺癌与酒精饮料消费

Breast cancer and alcoholic-beverage consumption.

作者信息

Rosenberg L, Slone D, Shapiro S, Kaufman D W, Helmrich S P, Miettinen O S, Stolley P D, Levy M, Rosenshein N B, Schottenfeld D, Engle R L

出版信息

Lancet. 1982 Jan 30;1(8266):267-70. doi: 10.1016/s0140-6736(82)90987-4.

Abstract

The relation between breast cancer and alcoholic-beverage consumption was evaluated in a case-control study of 1152 women with breast cancer and two groups of control women-519 with endometrial or ovarian cancer, and 2702 with non-malignant disorders. The relative-risk estimate of breast cancer, with allowance for all potential distorting factors, for women who had ever drunk alcoholic beverages relative to those who had never drunk was 1.4 (95% confidence interval, 1.0-2.0) when the comparison group was the group with endometrial or ovarian cancer and 1.9 (1.5-2.4) when the controls who had non-malignant disorders were the comparison group. The association was evident for beer, wine, and spirits. The association was not explained by any of the major known risk factors for breast cancer, but we had no information on dietary factors. The findings support the hypothesis that alcohol consumption, or related dietary factors, increases the risk of breast cancer.

摘要

在一项病例对照研究中,对1152名乳腺癌女性患者以及两组对照女性(519名子宫内膜癌或卵巢癌患者和2702名患有非恶性疾病的患者)进行了评估,以研究乳腺癌与酒精饮料消费之间的关系。在以子宫内膜癌或卵巢癌患者为对照组时,对曾经饮用酒精饮料的女性与从未饮用过酒精饮料的女性相比,考虑到所有潜在干扰因素后,乳腺癌的相对风险估计值为1.4(95%置信区间为1.0 - 2.0);当以患有非恶性疾病的患者为对照组时,相对风险估计值为1.9(1.5 - 2.4)。啤酒、葡萄酒和烈酒均存在这种关联。这种关联无法用任何已知的主要乳腺癌风险因素来解释,但我们没有关于饮食因素的信息。这些发现支持了酒精消费或相关饮食因素会增加乳腺癌风险这一假设。

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