Talamini R, La Vecchia C, Decarli A, Franceschi S, Grattoni E, Grigoletto E, Liberati A, Tognoni G
Br J Cancer. 1984 Jun;49(6):723-9. doi: 10.1038/bjc.1984.114.
The relation of breast cancer to social and dietary variables was evaluated in a case-control study of 368 women with breast cancer admitted to the General Hospital of Pordenone (a town in the eastern side of Northern Italy) and 373 age-matched controls. Occupation was related to the risk of breast cancer, housewives and non-manual workers (teachers and other professionals, clerical workers, etc.) showing relative risks of 1.7 and 2.4 respectively when compared to women occupied in agriculture. The role of education was apparently less important, and not statistically significant. The risk was higher in women who were obese, the trend of increasing risk with increasing body mass index being confined to post-menopausal women. When indicators of dietary fat intake were analysed, a significantly increased risk was found with more frequent consumption of milk and dairy products but the risk estimates were only slightly above unity with reference to meat consumption. Women who drank alcoholic beverages showed a relative risk of 2.5 compared to women who had never drunk, when allowance was made for all identified potential confounding factors. The association between alcohol and breast cancer was not explained by the other dietary variables considered, and the risk estimates were higher for women who drank more wine, or more than one type of alcoholic beverage. Thus, the findings of the present study give evidence in favour of the hypothesis that alcohol consumption is related to the risk of breast cancer.
在一项病例对照研究中，对368名入住波代诺内综合医院（意大利北部东部的一个城镇）的乳腺癌女性患者和373名年龄匹配的对照者进行了评估，以研究乳腺癌与社会及饮食变量之间的关系。职业与乳腺癌风险相关，家庭主妇和非体力劳动者（教师及其他专业人员、文职人员等）与从事农业的女性相比，相对风险分别为1.7和2.4。教育的作用显然不那么重要，且无统计学意义。肥胖女性的风险更高，风险随体重指数增加而上升的趋势仅限于绝经后女性。在分析膳食脂肪摄入指标时，发现牛奶和乳制品消费频率越高，风险显著增加，但肉类消费的风险估计仅略高于1。在考虑了所有已确定的潜在混杂因素后，饮酒女性与从未饮酒的女性相比，相对风险为2.5。酒精与乳腺癌之间的关联无法用所考虑的其他饮食变量来解释，饮酒较多或饮用不止一种酒精饮料的女性风险估计更高。因此，本研究结果支持酒精消费与乳腺癌风险相关这一假设。
