Longnecker M P
Department of Epidemiology, UCLA School of Public Health 90024-1772.
Cancer Causes Control. 1994 Jan;5(1):73-82. doi: 10.1007/BF01830729.
The objective was to evaluate the association between alcohol consumption and risk of breast cancer. Data from 38 epidemiologic studies on alcohol consumption in relation to risk of breast cancer in women were included in a meta-analysis. A qualitative literature review also was conducted. The results showed strong evidence of a dose-response relation; however, the slope of the dose-response curve was quite modest. For example, daily consumption of one alcoholic drink was associated with an 11 percent increase (95 percent confidence interval, seven to 16 percent) in the risk of breast cancer compared with nondrinkers. An explanation for the marked variation in results across studies was not found. The modest size of the association and variation in results across studies leave the causal role of alcohol in question. The evidence that alcohol consumption affects the risk of breast cancer, however, appears to be growing stronger.
目的是评估饮酒与乳腺癌风险之间的关联。一项荟萃分析纳入了38项关于饮酒与女性乳腺癌风险关系的流行病学研究数据。还进行了定性文献综述。结果显示有强有力的证据表明存在剂量反应关系；然而，剂量反应曲线的斜率相当平缓。例如，与不饮酒者相比，每天饮用一杯酒精饮料会使患乳腺癌的风险增加11%（95%置信区间为7%至16%）。未发现各研究结果存在显著差异的原因。这种关联规模较小且各研究结果存在差异，使得酒精的因果作用存疑。然而，饮酒影响乳腺癌风险的证据似乎越来越确凿。
