Szabo S, Usadel K H
Experientia. 1982 Feb 15;38(2):254-6. doi: 10.1007/BF01945097.
In rats, the hemorrhagic gastric erosions produced by ethanol, and the fatal hemorrhagic hepatic necrosis induced by phalloidin, were significantly reduced by regular somatostatin, but not by derivatives devoid of -SH containing cysteines. These effects of the hormone were abolished in animals which received, in addition, the sulfhydryl blocker n-ethylmaleimide before the toxic chemicals. Thus, somatostatin exhibits organoprotection dependent on endogenous sulfhydryls.
在大鼠中，乙醇所致的出血性胃糜烂以及鬼笔环肽诱导的致死性出血性肝坏死，均可被常规的生长抑素显著减轻，但不含半胱氨酸巯基的衍生物则无此作用。在给予有毒化学物质之前，预先接受巯基阻断剂N-乙基马来酰胺的动物，该激素的这些作用消失。因此，生长抑素表现出依赖内源性巯基的器官保护作用。
