Wehr T A, Goodwin F K, Wirz-Justice A, Breitmaier J, Craig C
Arch Gen Psychiatry. 1982 May;39(5):559-65. doi: 10.1001/archpsyc.1982.04290050037008.
Wrist motor activity and sleep were monitored longitudinally in 15 rapidly cycling and 52 nonrapidly cycling manic-depressive patients. The majority of patients experienced one or more consecutive 48-hour sleep-wake cycles (alternate nights with no sleep) when they switched out of depression into mania of hypomania. During a depressive phase, nine rapidly cycling patients were asked to simulate a 48-hour sleep-wake cycle by remaining awake for 40 hours (one night's total sleep deprivation). Eight switched out of depression, and seven were rated as manic or hypomanic; indicating that sleep loss (such as occurs with spontaneous 48-hour sleep-wake cycles) may help to trigger switches from depression to mania. The 48-hour sleep-wake cycles in patients may depend on a mechanism that is normally present in all humans, since normal persons also spontaneously experience near-48 hour sleep-wake cycles in certain experimental conditions.
对15名快速循环型和52名非快速循环型躁郁症患者的手腕运动活动和睡眠情况进行了纵向监测。大多数患者在从抑郁状态转变为轻躁狂或躁狂状态时，经历了一个或多个连续的48小时睡眠-清醒周期（交替的无睡眠夜晚）。在抑郁阶段，9名快速循环型患者被要求通过保持清醒40小时（一夜完全睡眠剥夺）来模拟一个48小时睡眠-清醒周期。其中8人摆脱了抑郁状态，7人被评定为躁狂或轻躁狂；这表明睡眠剥夺（如自发的48小时睡眠-清醒周期中出现的情况）可能有助于引发从抑郁到躁狂的转变。患者的48小时睡眠-清醒周期可能依赖于一种所有人类正常都存在的机制，因为正常人在某些实验条件下也会自发经历接近48小时的睡眠-清醒周期。
