卤代乙烯的代谢
Metabolism of halogenated ethylenes.
作者信息
Leibman K C, Ortiz E
出版信息
Environ Health Perspect. 1977 Dec;21:91-7. doi: 10.1289/ehp.772191.
Abstract
The metabolism of the chlorinated ethylenes may be explained by the formation of chloroethylene epoxides as the first intermediate products. The evidence indicates that these epoxides rearrange with migration of chlorine to form chloroacetaldehydes and chloroacetyl chlorides. Thus, monochloroacetic acid, chloral hydrate, and trichloroacetic acid have been found in reaction mixtures of 1,1-dichloroethylene, trichloroethylene, and tetrachloroethylene, respectively, with rat liver microsomal systems. Rearrangements of the chloroethylene, and glycols formed from the epoxides by hydration may also take place, but would appear, at least in the case of 1,1-dichloroethylene, to be quantitatively less important. The literature on the metabolism of chlorinated ethylenes and its relationship to their toxicity is reviewed.
摘要
氯化乙烯的代谢过程可以通过氯乙烯环氧化物作为首个中间产物的形成来解释。证据表明，这些环氧化物会随着氯的迁移而重排，形成氯乙醛和氯乙酰氯。因此，在1,1 - 二氯乙烯、三氯乙烯和四氯乙烯与大鼠肝脏微粒体系统的反应混合物中，分别发现了一氯乙酸、水合氯醛和三氯乙酸。氯乙烯的重排以及环氧化物水合形成的二醇也可能发生，但至少在1,1 - 二氯乙烯的情况下，从数量上看似乎不太重要。本文综述了关于氯化乙烯代谢及其与毒性关系的文献。
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本文引用的文献
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THE METABOLISM OF 36C1-LABELLED TRICHLOROETHYLENE AND TETRACHLOROETHYLENE IN THE RAT.大鼠体内36C1标记的三氯乙烯和四氯乙烯的代谢
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The role of alcohol dehydrogenase in the metabolism of chloral hydrate.
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Urinary metabolites of 14C-tetrachloroethylene in mice.小鼠体内14C-四氯乙烯的尿液代谢物
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Pharmacology and toxicology of trichloroethylene. A critical review of the literature.三氯乙烯的药理学与毒理学。文献综述
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Metabolism of trichloroethylene in liver microsomes. 3. Induction of the enzymic activity and its effect on excretion of metabolites.三氯乙烯在肝微粒体中的代谢。3. 酶活性的诱导及其对代谢物排泄的影响。
J Pharmacol Exp Ther. 1967 Sep;157(3):574-80.
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Metabolism of trichloroethylene in liver microsomes. II. Identification of the reaction product as chloral hydrate.三氯乙烯在肝微粒体中的代谢。II. 反应产物为水合氯醛的鉴定。
Mol Pharmacol. 1965 Nov;1(3):247-54.
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The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. 3. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes.芳烃氧化物-氧杂环庚三烯体系在芳香族底物代谢中的作用。3. 肝微粒体由萘生成1,2-萘氧化物。
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