氯化乙烯在离体灌注大鼠肝脏制剂中的化学反应性、代谢环氧乙烷的形成及生物活性。 - Suppr

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超能文献

Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation.

作者信息

Bonse G, Urban T, Reichert D, Henschler D

出版信息

Biochem Pharmacol. 1975 Oct 1;24(19):1829-34. doi: 10.1016/0006-2952(75)90468-2.

DOI:10.1016/0006-2952(75)90468-2

PMID:1233985

Abstract

摘要

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Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation.氯化乙烯在离体灌注大鼠肝脏制剂中的化学反应性、代谢环氧乙烷的形成及生物活性。

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Metabolic activation of vinyl chloride, formation of nucleic acid adducts and relevance to carcinogenesis.氯乙烯的代谢活化、核酸加合物的形成及其与致癌作用的关系。

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Evidence of chloroethylene oxide being the reactive metabolite of vinyl chloride towards DNA: comparative studies with 2,2'-dichlorodiethylether.环氧氯乙烯作为氯乙烯对DNA的反应性代谢产物的证据：与2,2'-二氯二乙醚的对比研究。

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Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.氯乙烯代谢产物的DNA反应产物1,N6-乙烯腺嘌呤和3,N4-乙烯胞嘧啶在体外DNA合成过程中的错编码特性研究。

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Limited capacity of humans to metabolize tetrachloroethylene.

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Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde.氯代环氧乙烷和氯乙醛的致突变性与毒性。

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Reproductive hazards related to perchloroethylene. A review.

Int Arch Occup Environ Health. 1989;61(4):235-42. doi: 10.1007/BF00381420.

Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites.用大鼠肝微粒体对14C-三氯乙烯蒸汽进行温育：放射性摄取及代谢产物与蛋白质的共价结合。

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Uptake and hepatotoxicity of 1,1-dichloroethylene by the isolated blood-perfused rat liver.1,1-二氯乙烯在离体血液灌注大鼠肝脏中的摄取及肝毒性

Int Arch Occup Environ Health. 1978 May 12;41(3):169-78. doi: 10.1007/BF00572889.

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