克罗恩病中功能性抑制性T细胞活性及柳氮磺胺吡啶的作用
Functional suppressor T cell activity in Crohn's disease and the effects of sulphasalazine.
作者信息
Holdstock G, Chastenay B F, Krawitt E L
出版信息
Clin Exp Immunol. 1982 Jun;48(3):619-24.
Abstract
Suppressor T cell activity was measured in 18 patients with Crohn's disease and 20 controls, using two different functional assays. The effects of sulphasalazine and its metabolites on in vitro suppressor cell activity were also studied. The activity of a Con A-induced suppressor cell system in patients with Crohn's disease did not differ from that of controls, suggesting that the previously reported abnormalities are a secondary phenomenon. Furthermore, the activity of a non-induced suppressor T cell system was also normal in these patients. There was no evidence either in vivo or in vitro to suggest that sulphasalazine exerts its beneficial action by an effect on this aspect of immunoregulation.
摘要
使用两种不同的功能测定方法，对18例克罗恩病患者和20名对照者的抑制性T细胞活性进行了测量。还研究了柳氮磺胺吡啶及其代谢产物对体外抑制性细胞活性的影响。克罗恩病患者中刀豆蛋白A诱导的抑制性细胞系统的活性与对照组无差异，这表明先前报道的异常是一种继发现象。此外，这些患者中未诱导的抑制性T细胞系统的活性也正常。无论是在体内还是体外，均没有证据表明柳氮磺胺吡啶通过对免疫调节的这一方面产生影响而发挥其有益作用。
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本文引用的文献
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