Kohler J, Schröter E, Cramer H
Arch Psychiatr Nervenkr (1970). 1982;231(6):503-8. doi: 10.1007/BF00343993.
Using a specific radioimmunoassay we have measured somatostatin-like immunoreactivity (SLIR) of CSF in patients with brain atrophy, spinal spasticity, seizures, brain tumors and inflammatory disorders. Patients with marked brain atrophy had significantly decreased somatostatin levels in CSF. In patients with spinal spasticity significantly higher levels were observed. Seizure patients had reduced levels but the difference was not significant. In patients with inflammatory disorders and malignant brain tumors SLIR levels were significantly elevated but not in patients with benign brain tumors. A possible pathophysiologic meaning of SLIR in spasticity and seizures is discussed. The altered levels in brain atrophy, tumors and inflammatory disorders are probably indirect signs of altered somatostatin turnover or increased somatostatin leakage from damaged CNS.
我们使用一种特定的放射免疫分析法，对脑萎缩、脊髓痉挛、癫痫、脑肿瘤和炎症性疾病患者脑脊液中的生长抑素样免疫反应性（SLIR）进行了测量。脑萎缩明显的患者脑脊液中生长抑素水平显著降低。脊髓痉挛患者的生长抑素水平明显更高。癫痫患者的生长抑素水平降低，但差异不显著。炎症性疾病和恶性脑肿瘤患者的SLIR水平显著升高，而良性脑肿瘤患者则不然。本文讨论了SLIR在痉挛和癫痫中可能的病理生理意义。脑萎缩、肿瘤和炎症性疾病中SLIR水平的改变可能是生长抑素代谢改变或受损中枢神经系统生长抑素泄漏增加的间接征象。
