Cramer H, Kohler J, Oepen G, Schomburg G, Schröter E
J Neurol. 1981;225(3):183-7. doi: 10.1007/BF00313747.
Somatostatin, substance P, cyclic AMP and cyclic GMP were determined in the cerebrospinal fluid of patients with Huntington's disease, in first generation relatives of choreic patients and in neurological control patients. Substance P levels were not significantly altered, but somatostatin levels were markedly decreased both in affected patients and symptom-free offspring. Cyclic AMP was decreased only in patients with advanced stages of the disease while cyclic GMP was normal. Evidence is discussed which may support a role of somatostatin deficiency in the pathophysiology of chorea.
对患有亨廷顿舞蹈症的患者、舞蹈症患者的第一代亲属以及神经科对照患者的脑脊液中的生长抑素、P物质、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）进行了测定。P物质水平没有显著变化，但无论是患病患者还是无症状后代，生长抑素水平均显著降低。环磷酸腺苷仅在疾病晚期患者中降低，而环磷酸鸟苷水平正常。文中讨论了可能支持生长抑素缺乏在舞蹈症病理生理学中起作用的证据。
