Patel Y, Rao K, Reichlin S
N Engl J Med. 1977 Mar 10;296(10):529-33. doi: 10.1056/NEJM197703102961002.
To determine whether somatostatin is found in the hypothalamus and extrahypothalamic brain, we studied autopsy brain tissue by specific immunoassay. The hypothalamus contained the highest concentration (16.7 +/- 2.4 S.D. pg per microgram of protein), with small amounts in brainstem, cerebral cortex, cerebellum, pineal gland and spinal cord. Cerebrospinal fluid of seven neurologically normal persons also contained somatostatin in concentrations ranging from 15 to 55 pg per milliliter. To determine whether brain disease leads to abnormal cerebrospinal-fluid somatostatin, we examined 30 patients with neurologic disease, of whom 20 of 24 with cord or cerebral disease had concentrations above the highest normal level. The wide variety of diseases with somatostatin elevation suggests nonspecific leakage from damaged brain tissue. Cerebrospinal-fluid somatostatin may provide a good index of brain damage. Although correlated statistically with cerebrospinal-fluid protein, somatostatin concentration in five of 24 cases exceeded the upper limit of normal by 3 S.D. while protein was normal.
为了确定下丘脑和下丘脑外的脑组织中是否存在生长抑素，我们通过特异性免疫测定法研究了尸检脑组织。下丘脑的浓度最高（每微克蛋白质16.7±2.4标准差皮克），脑干、大脑皮层、小脑、松果体和脊髓中含量较少。7名神经系统正常者的脑脊液中也含有生长抑素，浓度范围为每毫升15至55皮克。为了确定脑部疾病是否会导致脑脊液生长抑素异常，我们检查了30例神经系统疾病患者，其中24例患有脊髓或脑部疾病的患者中有20例的浓度高于正常最高水平。生长抑素升高的疾病种类繁多，提示受损脑组织存在非特异性渗漏。脑脊液生长抑素可能是脑损伤的一个良好指标。虽然与脑脊液蛋白有统计学相关性，但24例中有5例的生长抑素浓度超过正常上限3个标准差，而蛋白正常。
