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钾对正常受试者血压影响的随机双盲交叉试验。

Randomised double-blind cross-over trial of potassium on blood-pressure in normal subjects.

作者信息

Khaw K T, Thom S

出版信息

Lancet. 1982 Nov 20;2(8308):1127-9. doi: 10.1016/s0140-6736(82)92787-8.

DOI:10.1016/s0140-6736(82)92787-8
PMID:6128451
Abstract

A randomised double-blind cross-over study of increased oral potassium 64 mmol a day versus placebo was conducted in 20 young healthy males on normal sodium unrestricted diet. A significantly greater proportion had lower systolic and diastolic blood-pressures on potassium than on placebo. The mean diastolic pressure was significantly lowered, by 2.4 mm Hg, during potassium supplementation. Change in diastolic pressure correlated negatively with change in 24-hour urinary potassium and positively which change in 24-hour urinary sodium/potassium ratio in individual subjects.

摘要

对20名健康年轻男性进行了一项随机双盲交叉研究,这些男性日常饮食为正常钠摄入且不受限制,研究比较了每天口服64毫摩尔钾与安慰剂的效果。与服用安慰剂相比,服用钾后收缩压和舒张压降低的比例显著更高。在补充钾期间,平均舒张压显著降低了2.4毫米汞柱。个体受试者的舒张压变化与24小时尿钾变化呈负相关,与24小时尿钠/钾比值变化呈正相关。

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