Wei N, Klippel J H, Huston D P, Hall R P, Lawley T J, Balow J E, Steinberg A D, Decker J L
Lancet. 1983 Jan 1;1(8314-5):17-22. doi: 10.1016/s0140-6736(83)91561-1.
The effects of intensive plasma exchange on the serological and clinical manifestations of mildly active systemic lupus erythematosus were evaluated in a controlled, double-blind trial. Twenty patients were randomised to receive either six 4-litre plasma exchanges or a seemingly identical control procedure over a 2-week period. Plasma exchange produced significant reductions in serum levels of IgG, IgM, IgA, and circulating immune complexes measured by an 125I-Clq binding assay. These serological measures returned to baseline 4 weeks after plasma exchange without a rebound above baseline values. Antibodies to DNA were reduced immediately after plasma exchange; however, they often returned to pre-treatment levels before the next procedure. No changes in any of the serological measures were observed in the control group. In sixteen of the eighteen patients who completed the clinical trial activity had either remained stable or improved; the frequency and degree of clinical improvement was the same in both plasma exchange and control groups.
在一项对照双盲试验中，评估了强化血浆置换对轻度活动系统性红斑狼疮血清学及临床表现的影响。20名患者被随机分为两组，一组在2周内接受6次每次4升的血浆置换，另一组接受看似相同的对照程序。通过125I-Clq结合试验检测发现，血浆置换使血清中IgG、IgM、IgA水平及循环免疫复合物显著降低。这些血清学指标在血浆置换后4周恢复至基线水平，且未反弹至基线值以上。血浆置换后抗DNA抗体立即减少；然而，在下一次治疗前它们常恢复至治疗前水平。对照组的任何血清学指标均未发生变化。在完成临床试验的18名患者中，有16名患者的病情保持稳定或有所改善；血浆置换组和对照组临床改善的频率和程度相同。
