来自牛阴茎退缩肌提取物中的抑制性物质不是一种腺嘌呤核苷酸。
The inhibitory material in extracts from the bovine retractor penis muscle is not an adenine nucleotide.
作者信息
Bowman A, Gillespie J S, Martin W
出版信息
Br J Pharmacol. 1979 Nov;67(3):327-8. doi: 10.1111/j.1476-5381.1979.tb08683.x.
Abstract
Methods are described for the removal of adenosine or purine nucleotides from extracts of bovine retractor penis muscle (BRP). These methods did not interfere with the biological test preparations. Removal of adenosine and purine nucleotides by these methods did not modify the inhibitory action of the extract on the BRP. The effect of the extract on the BRP resembles that of inhibitory nerve stimulation. If the inhibitory substance present in the extract is the inhibitory transmitter, then the results indicate that, in this tissue, the transmitter is neither adenosine nor a purine nucleotide.
摘要
描述了从牛阴茎海绵体肌（BRP）提取物中去除腺苷或嘌呤核苷酸的方法。这些方法不会干扰生物测试制剂。通过这些方法去除腺苷和嘌呤核苷酸不会改变提取物对BRP的抑制作用。提取物对BRP的作用类似于抑制性神经刺激的作用。如果提取物中存在的抑制物质是抑制性递质，那么结果表明，在该组织中，递质既不是腺苷也不是嘌呤核苷酸。
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本文引用的文献
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The rat anococcygeus muscle and its response to nerve stimulation and to some drugs.大鼠肛门尾骨肌及其对神经刺激和某些药物的反应。
Br J Pharmacol. 1972 Jul;45(3):404-16. doi: 10.1111/j.1476-5381.1972.tb08097.x.
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Contraction and relaxation of the retractor penis muscle and the penile artery of the bull.公牛阴茎退缩肌和阴茎动脉的收缩与舒张。
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Purinergic nerves.嘌呤能神经
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5
6
Extraction from ox retractor penis of an inhibitory substance which mimics its atropine-resistant neurogenic relaxation.从牛阴茎退缩肌中提取一种模拟其抗阿托品神经源性舒张作用的抑制性物质。
Br J Pharmacol. 1975 Jul;54(3):409-10. doi: 10.1111/j.1476-5381.1975.tb07585.x.
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