Naughton J
Circulation. 1983 Jun;67(6 Pt 2):I106-9.
Beta-blocker therapy apparently is important in the short- and long-term care of patients with myocardial infarction (MI). In the former, administration may reduce MI size, and in the latter, it promotes a statistically significant reduction in mortality. Since beta blockers exert a number of effects, it is still not known how the specific beneficial effects are mediated. Nevertheless, there is still a need to examine the effects of beta blockers, either singly or combined with other medications, on patients recovering from acute MI and as a late intervention. Specific attention must be directed to the older patient, those with moderate myocardial dysfunction, and those with life-threatening ventricular dysrhythmias. Each of these problems must be addressed by a well-designed, randomized clinical trial to ensure the best possible study design and the most accurate scientific outcome.
β受体阻滞剂疗法显然在心肌梗死（MI）患者的短期和长期护理中都很重要。在短期内，使用β受体阻滞剂可能会减小梗死面积，而在长期护理中，它能使死亡率在统计学上显著降低。由于β受体阻滞剂具有多种作用，其具体的有益作用是如何介导的仍不清楚。然而，仍然有必要研究β受体阻滞剂单独使用或与其他药物联合使用时，对急性心肌梗死康复期患者的影响以及作为晚期干预措施的效果。必须特别关注老年患者、中度心肌功能不全患者以及有危及生命的室性心律失常的患者。这些问题中的每一个都必须通过精心设计的随机临床试验来解决，以确保最佳的研究设计和最准确的科学结果。
