Moore N A, Axton M S
Lilly Research Centre, Eli Lilly and Co., Windlesham, Surrey, UK.
Psychopharmacology (Berl). 1988;94(2):263-6. doi: 10.1007/BF00176857.
The ability of SKF38393 (a D1 agonist), quinpirole (a D2 agonist), and apomorphine (a mixed D1/D2 agonist) to induce stereotyped climbing behaviour in mice was investigated. Apomorphine produced a dose-related increase in stereotyped cage climbing which lasted for up to 60 min. SKF38393 and quinpirole failed to produce climbing when administered alone. When given in combination intense apomorphine-like cage climbing was observed which lasted for up to 2 h. Apomorphine or the combination of SKF38393 and quinpirole also produced biting of the cage. The climbing behaviour produced by either apomorphine or SKF38393/quinpirole combinations was antagonised by either the D1 antagonist, SCH23390 or the D2 antagonist clebopride. These results demonstrate that both D1 and D2 receptor activation is necessary to produce apomorphine-like cage climbing in mice.
研究了SKF38393（一种D1激动剂）、喹吡罗（一种D2激动剂）和阿扑吗啡（一种D1/D2混合激动剂）诱导小鼠刻板攀爬行为的能力。阿扑吗啡引起刻板的笼内攀爬行为呈剂量依赖性增加，持续长达60分钟。单独给予SKF38393和喹吡罗未产生攀爬行为。当联合给药时，观察到强烈的类似阿扑吗啡的笼内攀爬行为，持续长达2小时。阿扑吗啡或SKF38393与喹吡罗的组合也会引起咬笼行为。阿扑吗啡或SKF38393/喹吡罗组合产生的攀爬行为可被D1拮抗剂SCH23390或D2拮抗剂氯波必利拮抗。这些结果表明，D1和D2受体激活对于在小鼠中产生类似阿扑吗啡的笼内攀爬行为都是必需的。
