Beech J N, Morris R J, Raisman G
J Neurochem. 1983 Aug;41(2):411-7. doi: 10.1111/j.1471-4159.1983.tb04757.x.
The density of the cell surface antigen, Thy-1, has been measured on the axonal plasma membrane of the optic and hypoglossal nerves, and on the sympathetic (preganglionic) chain of the superior cervical ganglion in the rat. For each, the amount of Thy-1 in a standard length of nerve was determined. The amount of axonal plasma membrane in a similar length was then measured by use of a computer graphics system which determined the total length of membrane in electron micrographs of cross sections of nerve. The axons of the two peripheral nerves were found to have a similar density (1100-1500 molecules/microns2) of Thy-1 on their surface, and this was two- to threefold higher than the density on axons of optic nerve (500 molecules/microns2). These figures indicate that the density of Thy-1 on the surface of these axons is somewhat lower than that found on the cells of the lymphoid system. Moreover, contrary to the impression gained from previous determinations of Thy-1 levels, axons in the peripheral nervous system do not necessarily have a lower density of Thy-1 on their surface than do those of the central nervous system.
已对大鼠视神经和舌下神经的轴突质膜以及颈上神经节的交感（节前）链上的细胞表面抗原Thy-1的密度进行了测量。对于每一种情况，都测定了标准长度神经中Thy-1的含量。然后使用计算机图形系统测量了相似长度的轴突质膜的量，该系统通过电子显微镜下神经横切面的图像确定膜的总长度。发现两条外周神经的轴突表面Thy-1的密度相似（1100 - 1500分子/微米²），这比视神经轴突表面的密度（500分子/微米²）高两到三倍。这些数据表明，这些轴突表面Thy-1的密度略低于淋巴系统细胞表面的密度。此外，与先前对Thy-1水平测定所得印象相反，外周神经系统中的轴突表面Thy-1的密度不一定低于中枢神经系统中的轴突。
