Nagington J, Gandy G, Walker J, Gray J J
Lancet. 1983 Aug 20;2(8347):443-6. doi: 10.1016/s0140-6736(83)90402-6.
An epidemic of echovirus 11 infections occurred in the Cambridge special-care baby unit during August to October, 1982. There were 21 confirmed infections in babies; 1 died, 1 recovered after resection of a kidney, 5 had meningitis, and 6 had respiratory symptoms. Normal human immunoglobulin which contained antibody to echovirus 11 was administered intramuscularly (250 mg) to give protection. None of the children given immunoglobulin immediately after delivery (205 doses) developed symptoms or ill-effects. Serological studies reinforced earlier evidence for the protective action of antibody, and it is considered that immunoglobulin is a valuable safeguard for exposed newborn infants.
1982年8月至10月期间，剑桥特殊护理婴儿病房发生了肠道病毒11型感染的疫情。婴儿中有21例确诊感染；1例死亡，1例在肾切除术后康复，5例患脑膜炎，6例有呼吸道症状。给婴儿肌肉注射了含有肠道病毒11型抗体的正常人免疫球蛋白（250毫克）以提供保护。分娩后立即接受免疫球蛋白注射的儿童（205剂）均未出现症状或不良反应。血清学研究进一步证实了抗体的保护作用，并且认为免疫球蛋白对暴露的新生儿是一种有价值的保护措施。
