Isaacs D, Dobson S R, Wilkinson A R, Hope P L, Eglin R, Moxon E R
Department of Paediatrics, John Radcliffe Hospital, Oxford.
Lancet. 1989 Mar 11;1(8637):543-5. doi: 10.1016/s0140-6736(89)90078-0.
Two babies in a neonatal unit presented on the same day with meningitis due to echovirus 11, which was thought to have been introduced by staff. At this time echovirus 11 was also isolated from the stools of eight other babies; five of them did not have signs of infection. No intervention was made except to emphasise the importance of handwashing. There was evidence of secondary spread to two babies who were both clinically well. The attack rate was twelve (29%) of forty-one babies exposed. Seven of the twelve infected babies were born before 30 weeks' gestation and would have had little or no maternal antibody, yet only two of the seven babies had signs of infection. Despite lack of special measures, all babies recovered. Most cases of horizontally acquired neonatal echovirus infection are mild: extreme measures in the management of outbreaks are unnecessary.
新生儿病房同一天有两名婴儿因肠道病毒11型感染患脑膜炎，据认为是工作人员带入的。此时，另外八名婴儿的粪便中也分离出肠道病毒11型；其中五名没有感染迹象。除强调洗手的重要性外未采取其他干预措施。有证据表明，两名临床状况良好的婴儿出现了二次传播。在41名暴露婴儿中，发病12例（29%）。12名受感染婴儿中有7名在妊娠30周前出生，几乎没有或根本没有母体抗体，但这7名婴儿中只有2名有感染迹象。尽管未采取特殊措施，所有婴儿均康复。大多数水平传播的新生儿肠道病毒感染病例症状轻微：爆发疫情时无需采取极端措施。
