Deml E, Oesterle D, Wiebel F J
Cancer Lett. 1983 Jul;19(3):301-4. doi: 10.1016/0304-3835(83)90098-8.
Treatment of adult female rats with a single dose of benzo[a]pyrene (BaP) fails to initiate preneoplastic enzyme-altered islands in their livers. Treatment with polychlorinated biphenyls (PCBs) at a dose which strongly induces aryl hydrocarbon(BaP)hydroxylase prior to BaP application and followed by promotion with PCBs causes the appearance of about 9 adenosine-5'-triphosphatase-deficient and 7 gamma-glutamyltranspeptidase-positive islands/cm2 after 12 weeks. PCB-pretreatment or promotion alone did not increase the BaP-dependent formation of islands above that of the PCB-treated controls (2-3 islands/cm2). The results suggest that upon alteration of its metabolism BaP causes the formation of preneoplastic lesions in the liver which become manifest by promotion.
用单剂量苯并[a]芘（BaP）处理成年雌性大鼠，未能在其肝脏中引发癌前酶改变岛。在用多氯联苯（PCBs）处理后，在施用BaP之前以强烈诱导芳烃（BaP）羟化酶的剂量处理，并随后用PCBs进行促癌，12周后每平方厘米出现约9个腺苷-5'-三磷酸酶缺乏和7个γ-谷氨酰转肽酶阳性岛。单独的PCB预处理或促癌并未使BaP依赖性岛的形成增加超过PCB处理对照组（每平方厘米2 - 3个岛）。结果表明，BaP代谢改变后会导致肝脏中癌前病变的形成，这些病变通过促癌而显现出来。
