McMichael A J, Gotch F M, Dongworth D W, Clark A, Potter C W
Lancet. 1983 Oct 1;2(8353):762-4. doi: 10.1016/s0140-6736(83)92297-3.
Influenza-A-virus-specific, HLA-restricted, cytotoxic T-cell immunity, measured in 189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell immunity is probably associated with the low prevalence of influenza-A-virus infection since 1978.
1977年至1982年的6年间，对189名志愿者进行检测，结果显示甲型流感病毒特异性、HLA限制的细胞毒性T细胞免疫自1978年起急剧下降。研究表明，甲型流感病毒的自然感染可增强细胞毒性T细胞记忆。自1978年以来，T细胞免疫力的下降可能与甲型流感病毒感染的低流行率有关。
