日间手术的术前用药。奥沙西泮与替马西泮的比较。

Preoperative medication for day-case surgery. A comparison between oxazepam and temazepam.

作者信息

Greenwood B K, Bradshaw E G

出版信息

Br J Anaesth. 1983 Oct;55(10):933-7. doi: 10.1093/bja/55.10.933.

DOI:10.1093/bja/55.10.933

Abstract

The effects of temazepam 20 mg, oxazepam 30 mg and placebo were compared when given as preoperative medication to patients undergoing day-case surgery. Temazepam caused a significant decrease in anxiety and produced sedation by 60 min, whereas those patients receiving oxazepam showed only minimal changes. Awakening time was prolonged with oxazepam but not with temazepam. Two hours after surgery, no significant sedation was recorded with either drug, and simple psychomotor testing showed unimpaired performance. Patient acceptability was high with both oxazepam and temazepam.

摘要

将替马西泮20毫克、奥沙西泮30毫克和安慰剂作为日间手术患者的术前用药进行了效果比较。替马西泮可使焦虑显著减轻，并在60分钟时产生镇静作用，而接受奥沙西泮的患者仅有轻微变化。奥沙西泮会延长苏醒时间，但替马西泮不会。术后两小时，两种药物均未记录到显著的镇静作用，简单的精神运动测试显示表现未受损害。奥沙西泮和替马西泮的患者接受度都很高。