Altmann K, Mukkur T K
Res Vet Sci. 1983 Sep;35(2):234-9.
Lambs sucking ewes immunised four to five weeks before parturition with crude preparations of K99 and purified K99 pili of single subunit composition were protected against challenge infection with heterologous enteropathogenic Escherichia coli strains. In contrast, the majority of lambs sucking sham-immunised ewes suffered severe diarrhoea and dehydration, followed by death in nearly half of the affected lambs. Protection was related to the presence of antibody in the colostral whey and lamb sera. K99-specific antibody activity in the colostral whey was found to be confined to IgM and IgG (IgG1 and IgG2) but not to the IgA class.
在分娩前四至五周用K99粗制品和单亚基组成的纯化K99菌毛免疫的母羊所哺乳的羔羊，可抵御异源性肠道致病性大肠杆菌菌株的攻击感染。相比之下，大多数吸食假免疫母羊乳汁的羔羊会出现严重腹泻和脱水，近一半受影响的羔羊随后死亡。保护作用与初乳乳清和羔羊血清中抗体的存在有关。发现初乳乳清中的K99特异性抗体活性仅限于IgM和IgG（IgG1和IgG2），而不包括IgA类。
