Brown F, Wild T F, Rowe L W, Underwood B O, Harris T J
J Gen Virol. 1976 May;31(2):231-7. doi: 10.1099/0022-1317-31-2-231.
The relatedness of swine vesicular disease virus (SVDV) and Coxsackie B5 virus has been studied by virus neutralization and immunodiffusion tests and by hybridization of the virus RNAs. Clearly defined differences between the two viruses were found by the three methods. Isolates of SVDV from several countries were very closely related but could be differentiated. Recent isolates of Coxsackie B5 virus also appeared to be similar but clear differences could be detected between these and the prototype (Faulkner) strain of the virus. The SVDV isolates were more closely related to the Faulkner strain than to the recent isolates of Coxsackie B5 virus. Perhaps of more importance, the Faulkner strain was more closely related to SVDV than it was to the recent Coxsackie B5 isolates. The significance of these observations in relation to the recent emergence of swine vesicular disease is discussed.
已通过病毒中和试验、免疫扩散试验以及病毒RNA杂交对猪水疱病病毒（SVDV）和柯萨奇B5病毒的相关性进行了研究。通过这三种方法发现了两种病毒之间明确的差异。来自几个国家的SVDV分离株密切相关，但可以区分。柯萨奇B5病毒的近期分离株似乎也相似，但在这些分离株与该病毒的原型（福克纳）株之间可以检测到明显差异。SVDV分离株与福克纳株的关系比与柯萨奇B5病毒的近期分离株更密切。也许更重要的是，福克纳株与SVDV的关系比与柯萨奇B5病毒的近期分离株更密切。讨论了这些观察结果与近期猪水疱病出现的相关性。
