Mukherjee S, Shukla S, Rosen A
Biol Psychiatry. 1984 Mar;19(3):337-45.
A test for agraphaesthesia and the face-hand test were administered to 75 DSM-III bipolar disorder patients. Twenty-five patients (33.3%) had abnormal findings on these tests. Abnormal findings were limited to the group of 54 patients with a history of long-term neuroleptic exposure. There was a strong correlation between the duration of cumulative neuroleptic exposure and the presence of abnormalities. In the group with long-term neuroleptic exposure, family history of affective disorders was negatively correlated with the presence of abnormalities. It appears that long-term neuroleptic exposure may be a contributory causal factor in the development of abnormal neurological signs in bipolar patients. A tendency toward more left-hand errors suggesting hemispheric integration dysfunction was noted in the patients exposed to long-term neuroleptics.
对75名符合《精神疾病诊断与统计手册》第三版（DSM-III）标准的双相情感障碍患者进行了失写症测试和面部-手部测试。25名患者（33.3%）在这些测试中出现异常结果。异常结果仅限于有长期使用抗精神病药物史的54名患者。累积使用抗精神病药物的时长与异常情况的出现之间存在很强的相关性。在长期使用抗精神病药物的患者组中，情感障碍家族史与异常情况的出现呈负相关。长期使用抗精神病药物似乎可能是双相情感障碍患者出现异常神经体征的一个促成因素。在长期使用抗精神病药物的患者中，发现存在更多左手错误的倾向，这表明存在半球整合功能障碍。
