撤药状态在吗啡诱导的小鼠回肠对乙酰胆碱超敏反应中作用的分析

Analysis of the role of withdrawal state in morphine-induced supersensitivity to acetylcholine in mouse ileum.

作者信息

Ramaswamy S, Pillai N P

出版信息

J Pharm Pharmacol. 1984 Apr;36(4):275-6. doi: 10.1111/j.2042-7158.1984.tb04369.x.

DOI:10.1111/j.2042-7158.1984.tb04369.x

Abstract

An attempt has been made to study the possible role played by the withdrawal state in morphine-induced supersensitivity to acetylcholine in mouse isolated ileum. Chronic morphine treatment for 5 days produced a significant supersensitivity to acetylcholine in the ileum. This supersensitivity was not altered significantly by the addition of morphine to the bathing medium--a measure to avoid the precipitation of the withdrawal state. This indicates that the supersensitivity obtained does not represent the state of withdrawal and is the result of chronic morphine treatment.

摘要

已尝试研究戒断状态在吗啡诱导的小鼠离体回肠对乙酰胆碱超敏反应中可能发挥的作用。连续5天进行慢性吗啡处理可使回肠对乙酰胆碱产生显著的超敏反应。向浴液中添加吗啡（一种避免戒断状态出现的措施），这种超敏反应并未显著改变。这表明所获得的超敏反应并不代表戒断状态，而是慢性吗啡处理的结果。