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皮肤试验在Q热康复者和接种疫苗者中作为抗原暴露指标及抗体回忆诱导剂的价值。

The value of skin test in Q fever convalescents and vaccinees as indicator of antigen exposure and inducer of antibody recall.

作者信息

Kazár J, Schramek S, Brezina R

出版信息

Acta Virol. 1984 Mar;28(2):134-40.

PMID:6145346
Abstract

The skin test (ST) with Q fever chemovaccine revealed more positive reactors than the serological examination by microagglutination (MA) test among humans, who had suffered from Q fever one to eleven years ago or who had been vaccinated with Q fever chemovaccine from three months to four years ago. When examining the sera harvested either at skin-testing or two weeks thereafter by MA test, seroconversion or rise in antibody titres were found to both main Coxiella burnetii (C. b.) antigens. The rise or appearance of antibody response was similar in Q fever convalescents and vaccinees, in the latter occurring more often in ST positive than in ST negative individuals. Results of ST at different postvaccination (p.v.) intervals corresponded well to those of lymphocyte transformation (LT) test, but not to those of inhibition of leukocyte migration ( ILM ) test.

摘要

对曾在1至11年前患过Q热或在3个月至4年前接种过Q热化学疫苗的人群进行检测,结果显示,与通过微量凝集(MA)试验进行的血清学检查相比,Q热化学疫苗皮肤试验(ST)呈现出更多阳性反应者。在皮肤试验时或之后两周采集血清,通过MA试验检测发现,两种主要的伯氏考克斯体(C. b.)抗原均出现了血清转化或抗体滴度升高的情况。Q热康复者和疫苗接种者的抗体反应升高或出现情况相似,在后者中,ST阳性个体比ST阴性个体更常出现这种情况。不同疫苗接种后(p.v.)间隔时间的ST结果与淋巴细胞转化(LT)试验结果高度相符,但与白细胞游走抑制(ILM)试验结果不相符。

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