Van de Perre P, Rouvroy D, Lepage P, Bogaerts J, Kestelyn P, Kayihigi J, Hekker A C, Butzler J P, Clumeck N
Lancet. 1984 Jul 14;2(8394):62-5. doi: 10.1016/s0140-6736(84)90240-x.
To evaluate acquired immunodeficiency syndrome (AIDS) in central Africa a prospective study was done in Kigali, Rwanda, where Kaposi's sarcoma (KS) is endemic. During a 4 week period, 26 patients (17 males and 9 females) were diagnosed. 16 patients had opportunistic infections, associated with KS in only 2; 1 had multifocal KS alone; and 9 had clinical conditions consistent with prodromes of AIDS. All patients had severe T-cell defects characterised by cutaneous anergy, a striking decrease in the number of helper T cells, and a decreased OKT4:OKT8 ratio (mean 0.27). 21 of the 22 adult patients were living in urban centres and many of them were in the middle to upper income bracket. Most of the men were promiscuous heterosexuals and 43% of the females were prostitutes. No patient had a history of homosexuality, intravenous drug abuse, or transfusion in the previous 5 years. This study suggests that AIDS is present in central Africa as an entity probably unrelated to the well-known endemic African KS. An association of an urban environment, a relatively high income, and heterosexual promiscuity could be a risk factor for AIDS in Africa.
为评估中非地区的获得性免疫缺陷综合征（艾滋病），在卢旺达基加利进行了一项前瞻性研究，当地卡波西肉瘤（KS）为地方病。在为期4周的时间里，共诊断出26例患者（17例男性和9例女性）。16例患者发生机会性感染，仅2例与KS相关；1例仅有多灶性KS；9例患者的临床状况符合艾滋病前驱症状。所有患者均有严重的T细胞缺陷，表现为皮肤无反应性、辅助性T细胞数量显著减少以及OKT4:OKT8比值降低（平均为0.27）。22例成年患者中有21例生活在城市中心，其中许多人属于中高收入阶层。大多数男性为滥交的异性恋者，43%的女性为妓女。所有患者在过去5年中均无同性恋、静脉注射吸毒或输血史。该研究表明，艾滋病在中非地区作为一种疾病实体存在，可能与非洲著名的地方性KS无关。城市环境、相对较高的收入以及异性滥交之间的关联可能是非洲艾滋病的一个危险因素。
